J&J > Pfizer?

A new analysis published in Cell shows that the adenovirus vector vaccine made by J&J, and some others might have been better than the Pfizer, mRNA vaccine. 

Both were developed under Operation Warp Speed under Trump. 

One was favored and pushed by Biden.

https://www.cell.com/iscience/pdf/S2589-0042(23)00810-6.pdf

https://twitter.com/moxlosllc/status/1655940293575987200?s=46&t=Y4fVsDnz2q8uZ3VNKeco4A

Vaccines-Biden stuck on impulse power

Trump’s Operation Warp Speed developed a 1st generation, new vaccine for a new virus in an astonishingly short time and was the highest benefit to cost ratio of any government program since the Manhattan Project.(1)

Unfortunately, Biden seems to be stuck in impulse drive and has done little to accelerate the development of the 2nd generation vaccine needed. 

Since early 2022 there have been calls to develop 2nd generation vaccines and since August 2022 it was clear that repeated mRNA boosters making essentially the same spike protein antigen was problematic. mRNA Boosters seem to cause B cells to switch from producing IgG1/3 to producing IgG4. This class switch was associated with a reduced capacity of the spike-specific antibodies to mediate antibody-dependent cellular phagocytosis and complement deposition  This reduction in booster vaccine efficacy was not seen with adenoviral vectors. (1)(2)

(1)https://marginalrevolution.com/marginalrevolution/2022/04/an-operation-warp-speed-for-nasal-vaccines.html

(2)https://www.science.org/doi/full/10.1126/sciimmunol.ade2798?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org